Fetroja overcomes the 3 major, often coexisting, Gram-negative resistance mechanisms1-6

Fetroja remains active in the presence of all these mechanisms, which often coexist in hard-to-treat pathogens such as A baumannii complex and P aeruginosa

  1. β-lactamase hydolysis

    inactivates drug

    Stable against all classes (A, B, C, and D) of β-lactamases, including serine-carbapenemases and metallo-β-lactamases (VIM, IMP, and NDM)7,8

  2. Efflux pump up-regulation

    expels β-lactams

    Active against isolates that are resistant due to efflux pump up-regulation1,5,6,8

  3. Porin channel changes

    limit drug access

    Active against pathogens that have a decrease or change in porin channels1,5-8