Fetroja overcomes 3 major mechanisms of resistance that defeat other β-lactams1-5

Fetroja overcomes 3 often coexisting, Gram-negative resistance mechanisms1-5

  1. β-lactamase hydolysis

    β-lactamase hydrolysis inactivates drug

    Fetroja is stable against all classes (A, B, C, and D) of β-lactamases, including serine carbapenemases and metallo-β-lactamases (VIM, IMP, and NDM)6,7

  2. Efflux pump up-regulation

    Efflux pump up-regulation expels β-lactams

    Fetroja is active against isolates that are resistant due to efflux pump up-regulation1,5

  3. Porin channel deletions

    Porin channel deletions limit drug access

    Fetroja is active against pathogens that have a decrease or change in porin channels1,6,7

Fetroja maintains activity in the presence of β-lactamase hydrolysis, efflux pump up-regulation, and porin channel deletions1,2,6,7