Fetroja overcomes 3 major mechanisms of carbapenem resistance1-3,5,6

Fetroja passively and actively enters cells1,2

…and overcomes resistance

Active transport allows for an additional method of entry into bacterial cells. Fetroja and other beta lactams can enter bacterial cell porin channels in the outer membrane and into the periplasm through passive diffusion. Fetroja can also enter bacterial cells through active transport, by utilizing the iron transport system. Fetroja then passes through the peptidoglycan layer and binds to penicillin-binding proteins on the inner membrane.

…and overcomes resistance

Unlike other beta lactams, when Fetroja encounters an altered porin channel that cannot be entered, Fetroja can overcome porin channel changes by entering through the iron transport system.

Fetroja is stable against all classes of beta-lactamases (A, B, C, and D)1. In vitro activity does not necessarily correlate with clinical efficacy.

Efflux pump up-regulation expels some beta-lactams from bacterial cells. Fetroja overcomes efflux pump up-regulation1,4-6 and maintains activity.

See a video of Fetroja in action