Fetroja has an extensive Gram-negative spectrum that includes hard-to-treat pathogens1

Activity in both in vitro and in clinical infections
Fetroja has demonstrated activity against the following Gram-negative bacteria, both in vitro and in clinical infections
HABP and VABP cUTI
Acinetobacter baumannii complex
Escherichia coli
Enterobacter cloacae complex
Klebsiella pneumoniae
Pseudomonas aeruginosa
Serratia marcescens
Escherichia coli
Enterobacter cloacae complex
Klebsiella pneumoniae
Proteus mirabilis
Pseudomonas aeruginosa
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In vitro activity
Fetroja demonstrated in vitro activity against the following Gram-negative bacteria, but the clinical significance is unknown.
  • At least 90% of the following bacteria exhibit an in vitro minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for cefiderocol
Achromobacter spp
Burkholderia cepacia complex
Citrobacter freundii complex
Citrobacter koseri
Klebsiella aerogenes
Klebsiella oxytoca
Morganella morganii
Proteus vulgaris
Providencia rettgeri
Stenotrophomonas maltophilia

Bacteria added as part of FDA approval for HABP/VABP indication.

Fetroja has demonstrated activity against rare Gram-negative pathogens such as Achromobacter spp and Burkholderia cepacia complex.1

Fetroja has activity in the presence of a variety of carbapenem-resistant mechanisms1-5

Resistance mechanism Description In vitro activity
Fetroja is stable against all known
classes of β-lactamase
(bold=carbapenemase)
Class A KPC, TEM, SHV, CTX-M, GES, L2
Class B (Metallo) IMP, VIM, NDM, L1
Class C AmpC, CMY
Class D OXA-23, OXA-24/40, OXA-48, OXA-51, OXA-58
Other mechanisms of carbapenem resistance
Porin channel deletions OmpK35/36 porin deletiona, OprD porin deletionb
Efflux pump up-regulation MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXYb
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a Present in K pneumoniae.
b Present in P aeruginosa.

In vitro activity does not necessarily correlate with clinical efficacy.

No cross-resistance with other antibacterials has been identified with Fetroja