FDA and CLSI recommendations for Fetroja antibiotic susceptibility testing

Breakpoints are based on a dosage regimen of 2 grams every 8 hours administered over 3 hours
FDA breakpoints for Fetroja can be found at FDA/STIC
CLSI breakpoints for Fetroja can be found in CLSI M100

Available susceptibility testing methods for Fetroja

BD BBL™ Sensi-Disc™ discs*:

  • Cefiderocol discs for use in the Kirby-Bauer disc diffusion method

HardyDisk™ (AST)*:

  • Disk diffusion method for cefiderocol

Thermo Scientific™ Oxoid™ Discs

  • Uses disc diffusion methods to determine microorganism susceptibility to cefiderocol

Thermo Scientific™ Sensititre™ AST Plates:

  • These plates do not require specialty media; standard Sensititre Mueller-Hinton broth is used for inoculation

Laboratory Specialists, Inc. (LSI)

  • Panel of clinical isolates for verification and validation

Liofilchem® ComASP®:

  • Cefiderocol broth microdilution panel test kits

CDC and FDA AR Isolate Panel

  • Includes pathogens with demonstrated cefiderocol clinical efficacy and breakpoints
BD BBL Sensi-Disc, Oxoid Discs, and HardyDisk can be performed on regular Mueller-Hinton agar plates.

Commercial AST methods for Fetroja testing do not require special media preparation, and Shionogi is committed to the continued improvement and development of AST methods for Fetroja