There is an urgent need for antibiotics that addresses carbapenem resistance in Gram-negative non-fermenters1,2

Priority 1 critical stamp alert for World Health Organization priority pathogen list need for new antibiotics

World Health Organization global priority pathogens list: Top needs for new and effective antibiotics1


Pseudomonas aeruginosa bacterium

Pseudomonas aeruginosa

carbapenem-resistant

Acinetobacter baumannii bacteria

Acinetobacter baumannii

carbapenem-resistant

Enterobacteriaceae bacteria

Enterobacteriaceaea

carbapenem-resistant, 3rd-generation cephalosporin-resistant


a Enterobacteriaceae include: Klebsiella pneumoniae, Escherichia coli, Enterobacter spp, Serratia spp, Proteus spp, Providencia spp, and Morganella spp.

The CDC, in its 2019 Antibiotic Resistance Threats report, lists carbapenem-resistant Acinetobacter and Enterobacteriaceae as urgent public health threats, and multidrug-resistant P aeruginosa as a serious threat2

Stenotrophomonas maltophilia bacteria

The non-fermenter Stenotrophomonas maltophilia is also an emerging pathogen3

  • Treatment is made more difficult by intrinsic antibacterial resistance to β-lactams, polymyxins, and many other classes of antimicrobials

Multidrug and carbapenem resistance have been reported in more than 60% of Acinetobacter spp4