Fetroja—the world’s only siderophore cephalosporin—uses iron to actively enter bacterial cells, along with passive porin entry1

To obtain iron for growth, bacteria produce siderophores, which bind to iron, and then actively transport the siderophore-bound iron into their cells to proliferate2
Fetroja is a unique cephalosporin with an attached catechol side-chain (siderophore), and uses iron like a “Trojan horse” to actively enter bacterial cells, in addition to passive entry via porin channels1,3,4

Fetroja’s unique structure uses iron like a “Trojan horse”1,3

Fetroja cefiderocol chemical structure showing cephalosporin linked to iron-binding siderophore, a catechol side-chain
Unique structure also provides stability against hydrolysis by all classes (A, B, C, and D) of β-lactamases1,5

Fetroja is the world’s only siderophore cephalosporin, and uses a “Trojan horse” strategy1,3