Fetroja actively enters cells and overcomes resistance1-3

Fetroja overcomes 3 major mechanisms of resistance that defeat other β-lactams1,4-7

Active transport allows for an additional method of entry into bacterial cells. Fetroja and other β-lactams can enter bacterial cell porin channels in the outer membrane and into the periplasm through passive diffusion. Fetroja can also enter bacterial cells through active transport, by utilizing the iron transport system. Fetroja then passes through the peptidoglycan layer and binds to penicillin-binding proteins on the inner membrane. Fetroja is stable against all classes of β-lactamases (A-D). Fetroja maintains activity despite efflux pump up-regulation.

Active transport through iron channels as well as passive diffusion through porin channels1-3

Stable against all classes of β-lactamases (A-D)1

Fetroja maintains activity despite efflux pump up-regulation1,7,8

See a video of Fetroja in action